Título:
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Natural immune response to Plasmodium vivax alpha-helical coiled
coil protein motifs and its association with the risk of P.
vivax malaria
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Autor/a:
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Cespedes, Nora; Li Wai Suen, Connie S. N.; Koepfli, Cristian; Franca, Camila T.; Felger, Ingrid; Nebie, Issa; Arévalo-Herrera, Myriam; Mueller, Ivo; Corradin, Giampietro; Herrera, Sócrates
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Abstract:
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Protein alpha-helical coiled coil structures are known to induce
antibodies able to block critical functions in different
pathogens. In a previous study, a total of 50 proteins of
Plasmodium vivax erythrocytic asexual stages containing
alpha-helical coiled coil structural motifs were identified in
silico, and the corresponding peptides were chemically
synthesized. A total of 43 peptides were recognized by naturally
acquired antibodies in plasma samples from both Papua New Guinea
(PNG) and Colombian adult donors. In this study, the association
between IgG antibodies to these peptides and clinical immunity
was further explored by measuring total IgG antibody levels to
24 peptides in baseline samples from a longitudinal study of
children aged 1-3 years (n = 164) followed for 16 months.
Samples were reactive to all peptides tested. Eight peptides
were recognized by >50% of individuals, whereas only one
peptide had < 20% reactivity. Children infected at baseline
were seropositive to 23/24 peptides. No significant association
was observed between antibody titers and age or molecular force
of infection, suggesting that antibody levels had already
reached an equilibrium. There was a strong association between
antibody levels to all peptides and protection against P. vivax
clinical episodes during the 16 months follow-up. These results
suggest that the selected coiled coil antigens might be good
markers of both exposure and acquired immunity to P. vivax
malaria, and further preclinical investigation should be
performed to determine their potential as P. vivax vaccine
antigens. |
Materia(s):
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-Plasmodium vivax -Resposta immunitària -Malària -Plasmodium vivax -Immune response -Malaria |
Derechos:
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cc by (c) Nora Céspedes et al., 2017
http://creativecommons.org/licenses/by/3.0/es/ |
Tipo de documento:
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Artículo Artículo - Versión publicada |
Editor:
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Public Library of Science (PLoS)
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Compartir:
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