Title:
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Ivermectin to reduce malaria transmission I. Pharmacokinetic and
pharmacodynamic considerations regarding efficacy and safety
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Author:
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Chaccour, Carlos; Hammann, Felix; Rabinovich, Regina
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Abstract:
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Ivermectin is an endectocide that has been used broadly in
single dose community campaigns for the control of
onchocerciasis and lymphatic filariasis for more than 30 years.
There is now interest in the potential use of ivermectin
regimens to reduce malaria transmission, envisaged as
community-wide campaigns tailored to transmission patterns and
as complement of the local vector control programme. The
development of new ivermectin regimens or other novel
endectocides will require integrated development of the drug in
the context of traditional entomological tools and endpoints.
This document examines the main pharmacokinetic and
pharmacodynamic parameters of the medicine and their potential
influence on its vector control efficacy and safety at
population level. This information could be valuable for trial
design and clinical development into regulatory and policy
pathways. |
Subject(s):
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-Malària -Medicina tropical -Farmacocinètica -Malaria -Tropical medicine -Pharmacokinetics |
Rights:
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cc by (c) Chaccour et al., 2017
http://creativecommons.org/licenses/by/3.0/es/ |
Document type:
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Article Article - Published version |
Published by:
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Biomed Central
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