Title:
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Positron emission tomography assessment of large vessel inflammation in patients with newly diagnosed, biopsy-proven giant cell arteritis: a prospective, case-control study
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Author:
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Prieto González, Sergio; Depetris, Marina; García Martínez, Ana; Espígol Frigolé, Georgina; Tavera Bahillo, Itziar; Corbera Bellalta, Marc; Planas Rigol, Ester; Alba Garibay, Marco Antonio; Hernández Rodríguez, José; Grau Junyent, Josep M. (Josep Maria); Lomeña Caballero, Francisco Juan; Cid Xutglà, M. Cinta
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Other authors:
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Universitat de Barcelona |
Abstract:
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BACKGROUND: Positron emission tomography (PET) scan is emerging as a promising imaging technique to detect large-vessel inflammation in giant cell arteritis (GCA). However, the lack of a standardised definition of arteritis based on (18)fluorodeoxyglucose (FDG) uptake is an important limitation to the use of PET scan for diagnostic purposes. OBJECTIVE: To prospectively assess the intensity and distribution of FDG uptake at different vascular territories in patients with newly diagnosed GCA compared with controls. METHODS: 32 consecutive, biopsy-proven, GCA patients treated with glucocorticoids for ≤3 days were included. The control group consisted of 20 individuals, who underwent PET/CT for cancer staging. Maximal standardised uptake value (SUVm) was calculated at four aortic segments, supraaortic branches and iliac-femoral territory. Sensitivity and specificity was calculated by receiver-operator characteristic curves (ROC) analysis. RESULTS: Mean SUVm was significantly higher in patients than in controls in all vessels explored and correlated with acute-phase reactants and serum IL-6. Mean of the SUVm at all the vascular territories had an area under the curve (AUC) of 0.830, and a cut-off of 1.89 yielded a sensitivity of 80% and a specificity of 79% for GCA diagnosis. There were no significant differences in AUC among the vascular beds examined. CONCLUSIONS: FDG uptake by large vessels has a substantial sensitivity and specificity for GCA diagnosis. |
Subject(s):
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-Arteritis de cèl·lules gegants -Càncer -Inflamació -Tomografia computada per emissió de fotó simple -Estudi de casos -Giant cell arteritis -Cancer -Inflammation -Single-photon emission computed tomography -Case studies |
Rights:
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(c) BMJ Publishing Group, 2014
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Document type:
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Article Article - Published version |
Published by:
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BMJ Publishing Group
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