Title:
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Combined treatment with environmental enrichment and (-)-epigallocatechin-3-gallate ameliorates learning deficits and hippocampal alterations in a mouse model of Down Syndrome
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Author:
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Catuara-Solarz, Silvina; Espinoa Carrasco, Jose; Erb, Ionas; Langohr, Klaus; González, Juan Ramon; Notredame, Cedric; Dierssen, Mara
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Other authors:
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Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa; Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica |
Abstract:
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Intellectual disability in Down syndrome (DS) is accompanied by altered neuro-architecture, deficient synaptic plasticity, and excitation-inhibition imbalance in critical brain regions for learning and memory. Recently, we have demonstrated beneficial effects of a combined treatment with green tea extract containing (-)-epigallocatechin-3-gallate (EGCG) and cognitive stimulation in young adult DS individuals. Although we could reproduce the cognitive-enhancing effects in mouse models, the underlying mechanisms of these beneficial effects are unknown. Here, we explored the effects of a combined therapy with environmental enrichment (EE) and EGCG in the Ts65Dn mouse model of DS at young age. Our results show that combined EE-EGCG treatment improved corticohippocampal-dependent learning and memory. Cognitive improvements were accompanied by a rescue of cornu ammonis 1 (CA1) dendritic spine density and a normalization of the proportion of excitatory and inhibitory synaptic markers in CA1 and dentate gyrus. |
Abstract:
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Peer Reviewed |
Subject(s):
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-Àrees temàtiques de la UPC::Matemàtiques i estadística::Probabilitat -Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística matemàtica::Anàlisi multivariant -Combinatorial probabilities -Multivariate analysis -Sampling (Statistics) -(-)-epigallocatechin-3-gallate -down Syndrome -Environmental Enrichment -Excitation-Inhibition Imbalance -neuroplasticity -Probabilitats -Anàlisi multivariable -Mostreig (Estadística) -Classificació AMS::60 Probability theory and stochastic processes::60C05 Combinatorial probability -Classificació AMS::62 Statistics::62H Multivariate analysis -Classificació AMS::62 Statistics::62D05 Sampling theory, sample surveys |
Rights:
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Document type:
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Article - Published version Article |
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