Title:
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Infant mortality and morbidity associated with preterm and
small-for-gestational-age births in Southern Mozambique: A
retrospective cohort study
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Author:
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García-Basteiro, Alberto L.; Quintó, Llorenç; Macete, Eusébio; Bardají, Azucena; González, Raquel; Nhacolo, Arsénio; Sigaúque, Betuel; Sacoor, Charfudin; Rupérez, María; Sicuri, Elisa; Bassat Orellana, Quique; Sevene, Esperança Júlia Pires; Menéndez, Clara
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Abstract:
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BACKGROUND: Preterm and small for gestational age (SGA) births
have been associated with adverse outcomes during the first
stages of life. We evaluated the morbidity and mortality
associated with preterm and SGA births during the first year of
life in a rural area of Southern Mozambique. METHODS: This is a
retrospective cohort study using previously collected data from
children born at the Manhica District Hospital in two different
periods (2003-2005 and 2010-2012). Newborns were classified as
being preterm and/or SGA or as babies not fulfilling any of the
previous conditions (term non-SGA). All children were followed
up for a year for morbidity and mortality outcomes. RESULTS: A
total of 5574 live babies were included in the analysis. The
prevalence of preterm delivery was 6.2% (345/5574); the
prevalence of SGA was 14.0% (776/5542) and 2.2% (114/5542) of
the children presented both conditions. During the neonatal
period, preterm delivery and SGA were associated with 13 (HR:
13.0, 95% CI 4.0-42.2) and 5 times (HR: 4.5, 95% CI: 1.6-12.6)
higher mortality compared to term non SGA babies. Risk of
hospitalization was only increased when both conditions were
present (IRR: 3.5, 95%CI: 1.5-8.1). Mortality is also increased
during the entire first year, although at a lower rate.
CONCLUSIONS: Neonatal and infant mortality rates are remarkably
high among preterm and SGA babies in southern Mozambique. These
increased rates are concentrated within the neonatal period.
Prompt identification of these conditions is needed to implement
interventions aimed at increasing survival of these high-risk
newborns. |
Subject(s):
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-Mortalitat infantil -Moçambic -Morbiditat -Infant mortality -Mozambique -Morbidity |
Rights:
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cc by (c) García-Basteiro et al., 2017
http://creativecommons.org/licenses/by/3.0/es/ |
Document type:
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Article Article - Published version |
Published by:
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Public Library of Science (PLoS)
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