Título:
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A Useful allene for the stereoselective synthesis of protected quaternary 2-amino-2-vinyl-1,3-diols
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Autor/a:
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Rodríguez Ramírez, Aleix; Ariza Piquer, Xavier; Contreras, Miguel A.; García Gómez, Jordi; Lloyd-Williams, Paul; Mercadal, Nerea; Sánchez Zarzalejo, Carolina
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Otros autores:
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Universitat de Barcelona |
Abstract:
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Treatment of readily available allene 1 with Cy2BH followed by addition of an aldehyde led to quaternary protected 2-amino-2-vinyl-1,3-diols in high yield and excellent stereochemical purity. The choice of benzoyl as N-protecting group is critical since the observed N- to O-Bz transfer during the process prevents later undesired isomerizations in the adducts and keeps all heteroatoms protected. |
Materia(s):
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-Síntesi orgànica -Aldehids -Esfingolípids -Inhibidors enzimàtics -Organic synthesis -Aldehydes -Sphingolipids -Enzyme inhibitors |
Derechos:
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(c) American Chemical Society , 2017
info:eu-repo/semantics/embargoedAccess |
Tipo de documento:
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Artículo Artículo - Versión aceptada |
Editor:
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American Chemical Society
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Compartir:
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