Título:
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The association between naturally acquired IgG subclass specific
antibodies to the PfRH5 invasion complex and protection from
Plasmodium falciparum malaria
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Autor/a:
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Weaver, Rupert; Reiling, Linda; Feng, Gaoqian; Drew, Damien R.; Mueller, Ivo; Siba, Peter; Tsuboi, Takafumi; Richards, Jack; Fowkes, Freya J. I.; Beeson, James G.
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Abstract:
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Understanding the targets and mechanisms of human immunity to
malaria is important for advancing the development of highly
efficacious vaccines and serological tools for malaria
surveillance. The PfRH5 and PfRipr proteins form a complex on
the surface of P. falciparum merozoites that is essential for
invasion of erythrocytes and are vaccine candidates. We
determined IgG subclass responses to these proteins among
malaria-exposed individuals in Papua New Guinea and their
association with protection from malaria in a longitudinal
cohort of children. Cytophilic subclasses, IgG1 and IgG3, were
predominant with limited IgG2 and IgG4, and IgG
subclass-specific responses were higher in older children and
those with active infection. High IgG3 to PfRH5 and PfRipr were
significantly and strongly associated with reduced risk of
malaria after adjusting for potential confounding factors,
whereas associations for IgG1 responses were generally weaker
and not statistically significant. Results further indicated
that malaria exposure leads to the co-acquisition of IgG1 and
IgG3 to PfRH5 and PfRipr, as well as to other PfRH invasion
ligands, PfRH2 and PfRH4. These findings suggest that IgG3
responses to PfRH5 and PfRipr may play a significant role in
mediating naturally-acquired immunity and support their
potential as vaccine candidates and their use as antibody
biomarkers of immunity. |
Materia(s):
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-Malària -Plasmodium falciparum -Sistema immunològic -Malaria -Plasmodium falciparum -Immune system |
Derechos:
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cc by (c) Weaver et al., 2016
http://creativecommons.org/licenses/by/3.0/es/ |
Tipo de documento:
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Artículo Artículo - Versión publicada |
Editor:
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Springer Nature
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Compartir:
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