Títol:
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Is the 23-valent pneumococcal polysaccharide vaccine useful in preventing community-acquired pneumonia?
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Autor/a:
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Izquierdo, Conchita; Salleras i Sanmartí, Lluís; Domínguez García, Àngela
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Altres autors:
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Universitat de Barcelona |
Abstract:
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Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32393 |
Abstract:
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Although bacteremic pneumococcal pneumonia is the most severe form of pneumonia, non-bacteremic forms are much more frequent. Laboratory methods for the diagnosis of nonbacteremic pneumococcal pneumonia have a low sensitivity and specificity, and therefore all-cause pneumonia has been proposed as a suitable outcome to evaluate vaccination effectiveness. This work reviews the epidemiology of community-acquired pneumonia (CAP) and evaluates the effectiveness of the 3-valent pneumococcal polysaccharide vaccine (PPV-23) in preventing CAP requiring hospitalization in people aged ≥65 years. We performed a case-control study in patients aged ≥65 years admitted through the emergency department who presented with clinical signs and symptoms compatible with pneumonia. We
included 489 cases and 1,467 controls and it was obtained a vaccine efectiveness of 23.6 (0.9-41.0). Our results suggest that PPV-23 vaccination is effective and reduces hospital admissions due to pneumonia in the elderly, strengthening the rationale for vaccination programmes in this age group. |
Matèries:
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-Farmacologia -Pneumònia adquirida a la comunitat -Vacunes -Pharmacology -Community-acquired pneumonia -Vaccines |
Drets:
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(c) Transworld Research Network , 2012
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Tipus de document:
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Capítol o part de llibre |
Publicat per:
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Transworld Research Network
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