Title:
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Stereoselective Synthesis of (-)-Spicigerolide
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Author:
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Georges, Yohan; Ariza Piquer, Xavier; García Gómez, Jordi
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Other authors:
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Universitat de Barcelona |
Abstract:
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(-)-Spicigerolide was enantioselectively synthesized from a protected (S)-lactaldehyde. The synthesis of the polyacetylated framework relied on two Zn-mediated stereoselective additions of alkynes to aldehydes as well as a regiocontrolled [3,3]-sigmatropic rearrangement of an allylic acetate. The pyranone moiety was constructed via ring-closing metathesis. |
Subject(s):
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-Plantes -Botànica mèdica -Citotoxicitat per mediació cel·lular -Càncer -Estereoquímica -Productes naturals -Síntesi orgànica -Plants -Medical botany -Cell-mediated cytotoxicity -Cancer -Stereochemistry -Natural products -Organic synthesis |
Rights:
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(c) American Chemical Society , 2009
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Document type:
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Article Article - Accepted version |
Published by:
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American Chemical Society
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