Solid-phase synthesis and DNA binding studies of dichloroplatinum(II) conjugates of dicarba analogues of octreotide as a new anticancer drugs

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Title:	Solid-phase synthesis and DNA binding studies of dichloroplatinum(II) conjugates of dicarba analogues of octreotide as a new anticancer drugs
Author:	Barragán, Flavia; Moreno Martínez, Virtudes; Marchán Sancho, Vicente
Other authors:	Universitat de Barcelona
Abstract:	The first dichloroplatinum(II) conjugates of dicarba analogues of octreotide , which is expected to act as a"tumour-targeting device", have been efficiently synthesized following a stepwise solid-phase approach; these compounds emulate the mechanism of cisplatin since they form a 1,2-intrastrand cross-link with two consecutive guanines of an oligonucleotide.
Subject(s):	-ADN -Química bioinorgànica -Quimioteràpia del càncer -Cèl·lules canceroses -Toxicitat dels medicaments -DNA -Bioinorganic chemistry -Cancer chemotherapy -Cancer cells -Drug toxicity
Rights:	(c) Barragán, Flavia et al., 2009
Document type:	Article Article - Accepted version
Published by:	Royal Society of Chemistry
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