The study area is located within the Central Andes, a complex region composed of different structural styles. The region is characterized by highly elevated basement cored ranges, which abruptly break the foreland plain. These ranges were uplifted mainly by deep detached high-angle faults or by the inversion of former extensional faults of the Cretaceous rift. Palaeozoic orogenies generated crustal scale discontinuities in the basement, some of them reactivated during the Andean orogeny. Sedimentary sequences and layers architecture in the basins bordering ranges recorded the tectonic evolution of the region. Basement, syn-rift, postrift and three foreland stages were interpreted in the seismic sections according to the arrangement of the horizons and the main outcropping geological units in bordering ranges. Based on seismic data sets and field data, here we document a particular style of activation of basement faults. Thick-skinned structures that are not always related to the tectonic inversion but to the reactivation of older basement anisotropies represent a paradox since they were not active during the rifting stage. A flat slab subduction and a subsequent angle recovery conditioned the structural evolution of the area.