Differential inhibition of the TGF-b signaling pathway in HCC cells using the small molecule inhibitor LY2157299 and the D10 monoclonal antibody against TGF-β receptor Type II

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Título:	Differential inhibition of the TGF-b signaling pathway in HCC cells using the small molecule inhibitor LY2157299 and the D10 monoclonal antibody against TGF-β receptor Type II
Autor/a:	Dituri, Francesco; Mazzocca, Antonio; Peidrò, Fernando Juan; Papappicco, Patrizia; Fabregat Romero, Isabel; De Santis, Flavia; Paradiso, Angelo; Sabbà, Carlo; Giannelli, Gianluigi
Otros autores:	Universitat de Barcelona
Abstract:	We investigated blocking the TGF-b signaling pathway in HCC using two small molecule inhibitors (LY2157299, LY2109761) and a neutralizing humanized antibody (D10) against TGF-bRII. LY2157299 and LY2109761 inhibited HCC cell migration on Laminin-5, Fibronectin, Vitronectin, Fibrinogen and Collagen-I and de novo phosphorylation of pSMAD2. LY2157299 inhibited HCC migration and cell growth independently of the expression levels of TGF-bRII. In contrast to LY2157299, D10 showed a reduction in pSMAD2 only after a short exposure. This study supports the use of LY2157299 in clinical trials, and presents new insights into TGF-b receptor cycling in cancer cells.
Materia(s):	-Anticossos monoclonals -Fosforilació -Càncer de fetge -Factors de creixement -Monoclonal antibodies -Phosphorylation -Liver cancer -Growth factors
Derechos:	cc-by (c) Dituri, Francesco et al., 2013 http://creativecommons.org/licenses/by/3.0/es
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Public Library of Science (PLoS)
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