No Differences of Immune Activation and Microbial Translocation
                Among HIV-infected Children Receiving Combined Antiretroviral
                Therapy or Protease Inhibitor Monotherapy

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RECERCAT Home > Universitat de Barcelona > ISGlobal - Institut de Salut Global de Barcelona > Articles publicats en revistes (ISGlobal) > View document

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Title:	No Differences of Immune Activation and Microbial Translocation Among HIV-infected Children Receiving Combined Antiretroviral Therapy or Protease Inhibitor Monotherapy
Author:	Falcon Neyra, Lola; Benmarzouk-Hidalgo, Omar J.; Madrid, Lola; Noguera Julian, Antoni; Fortuny Guasch, Claudia; Neth, Olaf; López Cortés, Luis F.
Abstract:	This is a cross-sectional study of 15 aviremic chronic HIV-infected children revealing no differences in immune activation (IA; HLA-DRCD38 CD4 and CD8 T cells, and sCD14) and microbial translocation (MT; lipopolysaccharides (LPS) and 16S rDNA) among HIV-infected patients under combined antiretroviral treatment (cART; n = 10) or ritonavir-boosted protease inhibitor monotherapy (mtPI/rtv; n = 5). In both cases, IA and MT were lower in healthy control children (n = 32). This observational study suggests that ritonavir boosted protease inhibitor monotherapy (mtPI/rtv) is not associated with an increased state of IA or MT as compared with children receiving cART.
Subject(s):	-Infants -Infeccions per VIH -Estudi de casos -Antiretrovirals -Children -HIV infections -Case studies -Antiretroviral agents
Rights:	(c) Wolters Kluwer Health, Inc., 2015
Document type:	Article Article - Published version
Published by:	Wolters Kluwer Health, Inc.
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