Compelling diagnostic definitions and evidence-based treatment recommendations for schizoaffective disorder are lacking, but clinicians can still develop an effective, individualized treatment regimen for patients with this condition. The steps necessary to help patients with schizoaffective disorder reach and maintain remission are to confirm the diagnosis, evaluate the patient's predictors of outcome, be aware of the available pharmacotherapeutic options and prescribe appropriate medications, and implement psychotherapy when patients achieve remission. In this brief activity, these essential steps are discussed and treatment recommendations are offered.