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Título:
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Chapter One – Larock Reaction in the synthesis of heterocyclic compounds
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Autor/a:
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Herraiz Cobo, Jesús; Albericio Palomera, Fernando; Álvarez Domingo, Mercedes
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Otros autores:
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Universitat de Barcelona |
Abstract:
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The indole ring is one of the most common features in natural products and small molecules with important bioactivity. Larock reported a new methodology for the synthesis of the indole ring system based on the palladium-catalyzed heteroannulation of 2-iodoaniline and substituted alkyne moieties. This procedure was subsequently extended to the preparation of other nitrogen- and oxygen- containing heterocycles. This is the process of choice for the synthesis of a large number of heterocyclic derivatives, as it provides outstanding regioselectivity and good to excellent yields. |
Materia(s):
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-Química orgànica -Síntesi orgànica -Compostos heterocíclics -Organic chemistry -Organic synthesis -Heterocyclic compounds |
Derechos:
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(c) Elsevier, 2015
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Tipo de documento:
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Artículo Artículo - Versión aceptada |
Editor:
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Elsevier
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