To access the full text documents, please follow this link: http://hdl.handle.net/2445/46996

Title:	New strategies in the modulation of fatty acid oxidation as a treatment for obesity
Author:	Herrero Rodríguez, Laura; Mera Nanín, Paula; Orellana Gavaldà, Josep Maria; Gurunathan, Chandrashekaran; Malandrino, Maria Ida; Mir, Joan Francesc; Makowski, Kamil; Pozo, Macarena; Arasa, Maria del Mar; Ariza Piquer, Xavier; Asins Muñoz, Guillermina; García Gómez, Jordi; García Hegardt, Fausto; Serra i Cucurull, Dolors
Other authors:	Universitat de Barcelona
Abstract:	Strategies that enhance fat degradation or reduce caloricfood intake could be considered therapeutic interventions to reduce notonly obesity, but also its associated disorders. The enzyme carnitinepalmitoyltransferase 1 (CPT1) is the critical rate-determining regulatorof fatty acid oxidation (FAO) and might play a key role in increasingenergy expenditure and controlling food intake. Our group has shownthat mice overexpressing CPT1 in liver are protected from weight gain,the development of obesity and insulin resistance. Regarding foodintake control, we observed that the pharmacological inhibition ofCPT1 in rat hypothalamus decreased food intake and body weight.This suggests that modulation of CPT1 activity and the oxidation offatty acids in various tissues can be crucial for the potential treatmentof obesity and associated pathologies.
Abstract:	Podeu consultar el llibre complet a: http://hdl.handle.net/2445/46988
Publication date:	2013-11-07
Subject(s):	-Investigació farmacèutica -Obesitat -Pharmaceutical research -Obesity
Rights:	(c) Transworld Research Network, 2013
Document type:	Book Part
Published by:	Transworld Research Network
Share:

Show full item record