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Título: | Calcium phosphate cements loaded with basic fibroblast growth factor: Delivery and in vitro cell response |
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Autor/a: | Perez, Roman; Kim, Tae-Hyun; Kim, Meeju; Jang, Jun-Hyeog; Ginebra Molins, Maria Pau; Kim, Hae-Won |
Otros autores: | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica; Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits; Centro de Investigación Biomédica en Red. Bioingeniería, Biomateriales y Nanomedicina; Tan'guk Taehakkyo |
Abstract: | biological responses, especially in terms of cell proliferation. Here, we used basic fibroblast growth factor (bFGF) in an -tricalcium phosphate cement with different initial powder sizes (coarse vs. fine; designated as CPC-C and CPC-F, respectively) and investigated the behavior of bFGF loading and release, as well as the effects on osteoblast responses. bFGF was loaded at 10 g/ml or 25 g/ml onto the set form of two types of CPCs, aiming to allow penetration into the pore structure and adsorption onto the cement crystallites. The CPC formulated with fine powder (CPC-F) had higher specific surface area and smaller-sized pores and retained slightly higher amounts of bFGF within the structure. The bFGF release study performed for 3 weeks showed a sustained-release profile; after an initial rapid release over approximately... |
Materia(s): | -Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials -Biomaterials -calcium phosphate cements -powder size -growth factor delivery -cell proliferation -bone regeneration -Biomaterials |
Derechos: | Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Tipo de documento: | Artículo - Versión publicada Artículo |
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