Enantioselective formal synthesis of ent-rhynchophylline and ent-isorhynchophylline

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Title:	Enantioselective formal synthesis of ent-rhynchophylline and ent-isorhynchophylline
Author:	Amat Tusón, Mercedes; Ramos, Carlos; Pérez Bosch, Maria; Molins i Grau, Elies; Florindo, Pedro; Santos, Maria M. M.; Bosch Cartes, Joan
Other authors:	Universitat de Barcelona
Abstract:	Starting from (S)-tryptophanol, a formal synthesis of ent-rhyncho-phylline and ent-isorhynchophylline, involving stereoselective cyclocondensation, spirocyclization, and alkylation reactions, and the final adjustment of the oxidation level at the oxindole and piperidine moieties, is reported.
Subject(s):	-Alcaloides -Síntesi asimètrica -Estereoquímica -Alkaloids -Asymmetric synthesis -Stereochemistry
Rights:	(c) Amat Tusón, Mercedes et al., 2013
Document type:	Article Article - Accepted version
Published by:	Royal Society of Chemistry
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