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Title:
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Network-based enrichment analysis of gene expression through protein-protein interaction data
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Author:
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Massanet Vila, Raimon; Fernández Albert, Francesc; Caminal Magrans, Pere; Perera Lluna, Alexandre
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Other authors:
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Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial; Universitat Politècnica de Catalunya. SISBIO - Senyals i Sistemes Biomèdics |
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Abstract:
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High-throughput analysis of gene expression data is subject to technological and statistical issues that confuse the underlying expression-condition associations. In this contribution a network-based candidate gene prioritization strategy was applied to the enrichment of a publicly available gene expression dataset, focused on the study of the mechanosensitivity of genes exposed to altered pulmonary matrix stiffness. Results
suggested that some genes which had not been taken into account in the original study could have an important role in the processes causing, or affected by, pulmonary fibrosis. |
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Abstract:
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Peer Reviewed |
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Subject(s):
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-Àrees temàtiques de la UPC::Informàtica::Sistemes d'informació
-Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica
-Genetics, Medical -- mathematical methods
-Pulmonary fibrosis
-Genètica mèdica -- Models matemàtics
-Fibrosi pulmonar |
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Rights:
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Document type:
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Article - Published version
Conference Object |
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Published by:
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IEEE
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Share:
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