Title:
|
Automatic non-invasive differentiation of obstructive and central hypopneas with nasal airflow compared to esophageal pressure
|
Author:
|
Morgenstern de Muller, Christian Rudolf; Schwaibold, Matthias; Randerath, Winfried J.; Bolz, Armin; Jané Campos, Raimon
|
Other authors:
|
Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial; Institut de Bioenginyeria de Catalunya; Universitat Politècnica de Catalunya. SISBIO - Senyals i Sistemes Biomèdics |
Abstract:
|
The differentiation of obstructive and central respiratory events is a major challenge in the diagnosis of sleep
disordered breathing. Esophageal pressure (Pes) measurement is the gold-standard method to identify these events but its
invasiveness deters its usage in clinical routine. Flattening patterns appear in the airflow signal during episodes of
inspiratory flow limitation (IFL) and have been shown with invasive techniques to be useful to differentiate between central and obstructive hypopneas. In this study we present a new method for the automatic non-invasive differentiation of obstructive and central hypopneas solely with nasal airflow. An overall of 36 patients underwent full night polysomnography with systematic Pes recording and a total of 1069 hypopneas
were manually scored by human experts to create a goldstandard annotation set. Features were automatically extracted
from the nasal airflow signal to train and test our automatic classifier (Discriminant Analysis). Flattening patterns were
non-invasively assessed in the airflow signal using spectral and time analysis. The automatic non-invasive classifier obtained a
sensitivity of 0.71 and an accuracy of 0.69, similar to the results obtained with a manual non-invasive classification algorithm.
Hence, flattening airflow patterns seem promising for the noninvasive differentiation of obstructive and central hypopneas. |
Abstract:
|
Peer Reviewed |
Subject(s):
|
-Àrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica -Hypopnea -- Diagnosis -Sleep apnea, obstructive -- Diagnosis -Son -- Aspectes fisiològics -Hipopnea |
Rights:
|
|
Document type:
|
Article - Published version Conference Object |
Share:
|
|