Use of Gene Ontology semantic information in protein interaction data visualization

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Title:	Use of Gene Ontology semantic information in protein interaction data visualization
Author:	Massanet Vila, Raimon; Caminal Magrans, Pere; Perera Lluna, Alexandre
Other authors:	Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial; Universitat Politècnica de Catalunya. SISBIO - Senyals i Sistemes Biomèdics
Abstract:	The Gene Ontology project is an effort to structure knowledge on biological products and processes by adding semantic information to them. This is done in a systematic way so that this additional information can be automatically processed. In this contribution a protein-protein interaction visualization algorithm is proposed, which combines protein interaction data with Gene Ontology semantic information. The information is integrated using a semantic distance measure defined in ontologies or taxonomies. Multidimensional scaling is applied to this measure and the output complements protein interaction data in building an interaction visualization map.
Abstract:	Peer Reviewed
Subject(s):	-Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica -Biology computing -Data visualisation -Ontologies (artificial intelligence) -Information services -Proteomics -Gene ontology project -Ontologies (Recuperació de la informació)
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Document type:	Article - Published version Conference Object
Published by:	IEEE Press. Institute of Electrical and Electronics Engineers
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