Título:
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A new gene-based association test for genome-wide association studies
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Autor/a:
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Buil, Alfonso; Martínez-Pérez, Angel; Perera Lluna, Alexandre; Rib, Leonor; Caminal Magrans, Pere; Soria, José Manuel
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Otros autores:
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Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial; Universitat Politècnica de Catalunya. SISBIO - Senyals i Sistemes Biomèdics |
Abstract:
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Genome-wide association studies are widely used today to discover genetic factors that modify the risk of complex diseases. Usually, these methods work in a SNP-by-SNP fashion. We present a gene-based test that can be applied in the context of genome-wide association studies. We compare both strategies, SNP-based and gene-based, in a sample of cases and controls for rheumatoid arthritis. We obtained different results using each strategy. The SNP-based test found the PTPN22 gene while the gene-based test found the PHF19-TRAF1-C5 region. That suggests that no single strategy performs better than another in all cases and that a certain underlying genetic architecture can be delineated more easily with one strategy rather than with another. |
Abstract:
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Peer Reviewed |
Materia(s):
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-Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica -Gene mapping -- Mathematical models -Single-nucleotide polymorphism -Rheumatoid arthritis -Artritis reumatoide -Genètica mèdica |
Derechos:
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Tipo de documento:
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Artículo - Versión publicada Artículo |
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