Title:
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Transcription factor binding site detection through position cross-mutual information variability analysis
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Author:
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Maynou Fernández, Joan; Vallverdú Ferrer, Montserrat; Clarià Sancho, Francesc; Gallardo Chacón, Joan Josep; Caminal Magrans, Pere; Perera Lluna, Alexandre
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Other authors:
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Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial; Universitat Politècnica de Catalunya. SISBIO - Senyals i Sistemes Biomèdics |
Abstract:
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Regulatory sequence detection is a fundamental challenge in computational biology. One key process in protein
synthesis starts with the binding of the transcription factor to its binding site. Different sites can show binding to the same
factor. This variability found in binding sequences increases the difficulty of their detection using computational algorithms. In
this manuscript, a method for the detection of binding sites is proposed, based on the correlation between binding sequence
positions through information theoretical measures. Efficiency values of the method are reported in the form of Receiver
Operating Characteristic curves on the detection of different transcription factors of the Saccharomyces cerevisiae organism.
We compare our results with other known motif detection Motif Discovery scan (MDscan). |
Abstract:
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Peer Reviewed |
Subject(s):
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-Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica -Biology computing -Molecular biophysics -Molecular configurations -Bensitivity analysis -Bioinformàtica |
Rights:
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Document type:
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Article - Published version Conference Object |
Published by:
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IEEE Press. Institute of Electrical and Electronics Engineers
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