Title:
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Actively maintained lipid nanodomains in biomembranes
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Author:
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Gomez, Jordi; Sagués i Mestre, Francesc; Reigada Sanz, Ramon
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Other authors:
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Universitat de Barcelona |
Abstract:
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Lipid rafts, defined as domains rich in cholesterol and sphingolipids, are involved in many important plasma membrane functions. Recent studies suggest that the way cells handle membrane cholesterol is fundamental in the formation of such lateral heterogeneities. We propose to model the plasma membrane as a nonequilibrium phase-separating system where cholesterol is dynamically incorporated and released. The model shows how cellular regulation of membrane cholesterol may determine the nanoscale lipid organization when the lipid mixture is close to a phase separation boundary, providing a plausible mechanism for raft formation in vivo. |
Subject(s):
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-Biofísica -Física mèdica -Química física -Colesterol -Membranes cel·lulars -Biophysics -Medical physics -Physical chemistry -Cholesterol -Cell membranes |
Rights:
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(c) American Physical Society, 2008
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Document type:
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Article Article - Published version |
Published by:
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The American Physical Society
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