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Improving the Quality of EEG Data in Patients With Alzheimers Disease Using ICA
Vialatte, François B.; Solé-Casals, Jordi; Maurice, Monique; Latchoumane, Charles-François V.; Hudson, Niegel; Wimalaratna, Sunil R.; Jaeseung, Jeonga; Cichocki, Andrej
Universitat de Vic. Escola Politècnica Superior; Universitat de Vic. Grup de Recerca en Tecnologies Digitals; International Conference on Neural Informations Processing (15è: 2008: Auckland); ICONIP 2008
Does Independent Component Analysis (ICA) denature EEG signals? We applied ICA to two groups of subjects (mild Alzheimer patients and control subjects). The aim of this study was to examine whether or not the ICA method can reduce both group di®erences and within-subject variability. We found that ICA diminished Leave-One- Out root mean square error (RMSE) of validation (from 0.32 to 0.28), indicative of the reduction of group di®erence. More interestingly, ICA reduced the inter-subject variability within each group (¾ = 2:54 in the ± range before ICA, ¾ = 1:56 after, Bartlett p = 0.046 after Bonfer- roni correction). Additionally, we present a method to limit the impact of human error (' 13:8%, with 75.6% inter-cleaner agreement) during ICA cleaning, and reduce human bias. These ¯ndings suggests the novel usefulness of ICA in clinical EEG in Alzheimer's disease for reduction of subject variability.
-Alzheimer, Malaltia d'
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