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Title:
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Effects of functional olive oil enriched with its own phenolic compounds on endothelial function in hypertensive patients. A Randomized Controlled Trial
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Author:
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Valls, Rosa M.; Farràs, Marta; Suárez, Manuel; Fernández Castillejo, Sara; Fitó, Montserrat; Konstantinidou, Valentini; Fuentes, Francisco; López-Miranda, José; Giralt, Montserrat; Covas Planells, María Isabel; Motilva Casado, Mª José; Solà, Rosa
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Notes:
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The additional health-promoting properties of functional virgin olive oil (FVOO) enriched with its own
phenolic compounds (OOPC) versus the parental virgin olive oil (VOO) must be tested in appropriate
human clinical trials. Our aim was to assess the effects of FVOO on endothelial function in hypertensive
patients. Thirteen pre- and stage-1 hypertensive patients received a single dose of 30 mL of FVOO
(OOPC = 961 mg/kg) or VOO (OOPC = 289 mg/kg) in a postprandial randomised, double blind, crossover
trial. Endothelial function, measured as ischemic reactive hyperemia (IRH) and related biomarkers, were
followed for 5 h after consumption. Compared with VOO, FVOO increased IRH (P < 0.05) and plasma Cmax
of hydroxytyrosol sulphate, a metabolite of OOPC 2 h postprandial (P = 0.05). After FVOO ingestion,
oxidised LDL decreased (P = 0.010) in an inverse relationship with IRH AUC values (P = 0.01). FVOO
provided more benefits on endothelial function than a standard natural virgin olive oil in pre- and
hypertensive patients. Trial registration: isrctn.org. Identifier ISRCTN03450153 |
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Subject(s):
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-Endothelial function
-Hypertension
-Olive oil phenols
-Functional olive oil |
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Rights:
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(c) Elsevier, 2015
info:eu-repo/semantics/restrictedAccess |
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Document type:
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Article
Article - Published version |
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Published by:
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Elsevier
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