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Title:
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β-catenin signalling in Glioblastoma multiforme and Glioma-initiating cells
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Author:
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Nàger Grifo, Mireia; Bhardwaj, Deepshikha; Cantí Nicolás, Carles; Medina Hernández, Loreta Mª; Nogués Bara, Pere; Herreros Danés, Judit
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Notes:
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Glioblastoma multiforme (GBM) is a commonly occurring brain tumor with a poor prognosis. GBM can develop both “de novo” or evolve from a previous astrocytoma and is characterized by high proliferation and infiltration into the surrounding tissue. Following treatment (surgery, radiotherapy, and chemotherapy), tumors often reappear. Glioma-initiating cells (GICs) have been identified in GBM and are thought to be responsible for tumors initiation, their continued growth, and recurrence.
β-catenin, a component of the cell-cell adhesion complex and of the canonical Wnt pathway, regulates proliferation, adhesion, and migration in different cell types. β-catenin and components of the Wnt canonical pathway are commonly overexpressed in GBM. Here, we review previous work on the role of Wnt/β-catenin signalling in glioma initiation, proliferation, and invasion. Understanding the molecular mechanisms regulating GIC biology and glioma progression may help in identifying novel therapeutic targets for GBM treatment. |
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Subject(s):
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-GBM
-GBM Recurrence
-Cervell -- Tumors
-Sistema nerviós central -- Tumors
-Càncer
-Cèl·lules -- Proliferació
-Neurobiologia
-Proteïnes -- Anàlisi |
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Rights:
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cc-by, (c) Mireia Nager et al., 2012
http://creativecommons.org/licenses/by/3.0/es/deed.ca
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Document type:
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article
publishedVersion |
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Published by:
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Hindawi Publishing Corporation
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Share:
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