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Título:
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Colonic perianastomotic carcinogenesis in an experimental model
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Autor/a:
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Pérez-Holanda Fernández, Sergio; Rodrigo, Luis; Piñol Felis, Carme; Viñas Salas, Joan
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Notas:
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Background
To examine the effect of anastomosis on experimental carcinogenesis in the colon of rats.
Methods
Forty-three 10-week-old male and female Sprague-Dawley rats were operated on by performing an end-to-side ileorectostomy. Group A:16 rats received no treatment. Group B: 27 rats received 18 subcutaneous injections weekly at a dose of 21 mg/kg wt of 1–2 dimethylhydrazine (DMH), from the eighth day after the intervention. Animals were sacrificed between 25–27 weeks. The number of tumours, their localization, size and microscopic characteristics were recorded. A paired chi-squared analysis was performed comparing tumoral induction in the perianastomotic zone with the rest of colon with faeces.
Results
No tumours appeared in the dimethylhydrazine-free group. The percentage tumoral area was greater in the perianastomotic zone compared to tumours which had developed in the rest of colon with faeces (p = 0.014).
Conclusion
We found a cocarcinogenic effect due to the creation of an anastomosis, when using an experimental model of colonic carcinogenesis induced by DMH in rats. |
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Materia(s):
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-Recte--Càncer
-Carcinogènesi |
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Derechos:
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cc-by, (c) Pérez-Holanda et al., 2008
http://creativecommons.org/licenses/by/2.0/es/deed.ca
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Tipo de documento:
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article
publishedVersion |
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Editor:
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BioMed Central
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Compartir:
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